eISSN:
3026-8273
Print ISSN:
1596-6941

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COMPARATIVE CHROMATOGRAPHIC ANALYSIS AND PHARMACODYNAMIC ACTIVITIES OF AQUEOUS MUSHROOM EXTRACTS (PLEUROTUS TUBER-REGIUM) WITH OTHER ANTIGLAUCOMA DRUGS

Ghalib A. Akinlabi, Kelly E. Omoruyi
Department of Optometry, University of Benin, Benin City.
Corresponding Author: gaakinlabi@uniben.edu; Tel: +2348186146373
Recieved Date: 2020; Accepted Date: 2020; Published Date: 2020
ABSTRACT

Experimental studies have shown that aqueous extract of Pleurotus tuber-regium (PT) caused a reduction in steroid induced ocular hypertension in feline models and a contractile effect on isolated bovine iris. A comparative thin layer chromatographic study and Ultraviolet-Visible spectrophotometric analysis (TLC-UVS) of PT in comparison with known antiglaucoma drugs (0.5% betaxolol, 0.5% timolol maleate, 2% pilocarpine, and 0.005% latanoprost) was carried out to identify their similarities.

Keywords: Antiglaucoma drugs, Chromatographic Analysis, Pharmacodynamics, Pleurotus tuber-regium
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