World Health Organization (WHO) in 2015 reported the prevalence of neurodegenerative diseases to be unacceptably high, with 3 out of 100 persons encountering neurological problems. Chemically synthesised drugs are available for the control of the diseases. However, use of the drugs is associated with unwanted side effects, thus, stimulating interest in the quest for natural neuroprotective substances to replace these drugs. Syzygium cumini is a medicinal plant that is often used in Nigeria for the treatment of inflammation, diabetes mellitus, pain, diarrhoea and ulcer. Different parts of the plant such as leaves, seed, fruit and stem have been claimed to show neuroprotection effects but much needs to be done in evaluating its role and therapeutic efficacy in neurodegenerative diseases. This review will focus on the neuroprotective effects of Syzygium cumini.
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